4/14/2023 0 Comments Dendrite branchingThese factors and signaling cascades may lead to the transcriptional activation of regulators of neuronal morphology. The patterning of dendrites is determined by extrinsic and intrinsic factors that promote the activation of cellular signaling pathways. FiresteinĪbstract: Processing of information by the central nervous system (CNS) depends on the dendritic morphology of postsynaptic neurons. Title: Novel Pharmacological Targets for Controlling Dendrite Branching and Growth During Neuronal DevelopmentĪuthor(s): Jose R. Keywords: Dendrite branching, dendrite development, signaling pathways, transcriptional regulation, neurotrophins, cypin, guanine deaminase, neurological disorders We discuss this novel intrinsic regulator of dendrite branching as an innovative pharmacological target for the use of computer-aided rational drug design to control guanine levels, microtubule assembly, and neuronal differentiation during CNS development and in disease states. Particular attention is directed towards a specific regulator of dendrite branching reported by our group, cypin (cytosolic PSD-95 interactor). In this review, we evaluate the potential of regulators of dendrite patterning as targets for drug design for the treatment of neurodegenerative diseases and altered neuronal growth in the CNS. Interestingly, when there is an abnormal decrease in the number of dendrite branches and disruption of proper networks, neurodegenerative diseases, including Rett Syndrome, autism, and mental retardation, may result. Processing of information by the central nervous system (CNS) depends on the dendritic morphology of postsynaptic neurons.
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